OSI-027

SKU: orb1300874

Description

OSI-027 (ASP4786) is a potent and selective dual mTORC1/mTORC2 inhibitor with IC50 values of 22 nM and 65 nM, respectively, demonstrating over 100-fold selectivity against related PI3K isoforms and DNA-PK. This tool compound has been utilized in preclinical research to investigate mTOR signaling in cancer models, both in vitro and in vivo, during its Phase 1 clinical development.

Research Area

Cell Biology, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 936890-98-1
• MW: 406.44
• Purity: ≥95% (May vary between batches)
• Formula: C₂₁H₂₂N₆O₃
• SMILES: COc1cccc2=C\C(N=c12)=c1/nc(C2CCC(CC2)C(O)=O)n2NC=NC(N)=c12
• Target: Autophagy,mTOR,DNA-PK,PI3K
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:15 mg/mL (36.91 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.92 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNA-PK, DNAPK, ASP 4786, ASP 7486, ASP-4786, ASP7486, ASP-7486, ASP4786, Autophagy, OSI 027, OSI027, OSI-027, mTOR, mTORC2, mTORC1, inhibit, Inhibitor, Mammalian target of Rapamycin, PI3Kγ

Quick Database Links

Gene Symbol

Autophagy,mTOR,DNA-PK,PI3K