Osimertinib mesylate

SKU: orb1303975

Description

Osimertinib mesylate is an orally active, irreversible third-generation EGFR inhibitor designed to target the T790M resistance mutation in non-small cell lung cancer. It is widely used in both in vitro biochemical assays and in vivo xenograft models to study resistance mechanisms and evaluate therapeutic efficacy against EGFR-mutant tumors.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 1421373-66-1
• MW: 595.71
• Purity: 98.65% (May vary between batches)
• Formula: C₂₉H₃₇N₇O₅S
• SMILES: CS(O)(=O)=O.COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cn(C)c2ccccc12
• Target: EGFR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.68 mM);DMSO:14 mg/mL (23.5 mM);H2O:20 mg/mL (33.57 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

tumor xenograft model, H1975, Epidermal growth factor receptor, EGFR, EGFR (L858R), EGFR (L858R/T790M), ErbB-1, HER1, Inhibitor, Mereletinib mesylate, Mereletinib Mesylate, Mereletinib, inhibit, Osimertinib Mesylate, Osimertinib mesylate, Osimertinib, PC-9, AZD-9291 mesylate, AZD-9291, AZD9291, AZD9291 Mesylate, AZD-9291 Mesylate, AZD 9291, AZD 9291 Mesylate, cancer, Ba/F3 cells

Quick Database Links

Gene Symbol

EGFR