OSS-128167

SKU: orb1302947

Description

OSS_128167 (SIRT6-IN-1) is a selective SIRT6 inhibitor with an IC50 of 89 µM, demonstrating over 17-fold selectivity against SIRT1 and SIRT2. This compound is a valuable chemical probe for investigating SIRT6 biology in cellular and biochemical assays related to aging, metabolism, and genomic stability.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 887686-02-4
• MW: 366.3
• Purity: >98%
• Formula: C₁₉H₁₄N₂O₆
• SMILES: OC(=O)c1cc(NC(=O)c2cccc(NC(=O)c3ccco3)c2)ccc1O
• Target: Protein deacetylase
• Solubility: Soluble in DMSO (25 mg/ml); or Ethanol (25 mg/ml)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TNF-α, PPARα, SIRT2, SIRT1, Sirtuin, SIRT6, SIRT6-IN-1, OSS_128167, immune, inhibit, Inhibitor, Hepatitis B virus, HBV, H3K9, GLUT-1, deacetylase, chemosensitization, diabetes, acetylation, antiviral, anti-cancer

Quick Database Links

Gene Symbol

Protein deacetylase