Oxaliplatin

SKU: orb1224440

Description

A platinum-based antineoplastic agent that works by blocking the duplication of DNA; forms both inter- and intra-strand cross links in DNA, prevents DNA replication and transcription, causing cell death.Chemotherapeutic Agents Approved(In Vitro):Oxaliplatin (24-72 hours; 2-128 μM; HCC, HCCLM3 and Hep3B cells) inhibits cell growth and induces apoptosis.Oxaliplatin (10 μM; 15-240 mins; CEM cells ) induces primary and secondary DNA lesions, including DNA cross-links (ISC) and DNA-protein cross-links (DPC).Oxaliplatin (0.01 to 100 μM; 24 hours) potently inhibits bladder carcinoma cell lines RT4 and TCCSUP, ovarian carcinoma cell line A2780, colon carcinoma cell line HT-29, glioblastoma cell lines U-373MG and U-87MG, and melanoma cell lines SK-MEL-2 and HT-144 with IC50 of 11 μM, 15 μM, 0.17 μM, 0.97 μM, 2.95 μM, 17.6 μM, 30.9 μM and 7.85 μM, respectively.(In Vivo):Oxaliplatin (5-10 mg/kg; i.p.; for 32 days; nude mice) inhibits tumor growth.

Key Properties

• CAS Number: 61825-94-3
• MW: 397.2917
• Purity: >98% (HPLC)
• Formula: C₈H₁₄N₂O₄Pt
• SMILES: O=C1[O-][Pt+2]2([O-]C1=O)[NH2]C3CCCCC3[NH2]2
• Target: DNA Alkylator
• Solubility: DMSO: 32 mg/mL (Need ultrasonic)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dacplat | Eloxatin? | Elplat | Lipoxal | NSC 266046 | RP 54780

Quick Database Links

Gene Symbol

DNA Alkylator