Pergolide mesylate salt

SKU: orb1224311

Description

PERGOLIDE MESYLATE is a long-acting dopamine agonist which has been used to treat parkinson disease and hyperprolactinemiabut withdrawn from some markets due to potential for heart valve diseases.(In Vitro):Pergolide (10 nM-50 μM) treatment dose-dependently inhibits H2O2-induced cell death in SH-SY5Y neuroblastoma cells. Pergolide protects SH-SY5Y neuroblastoma cells from cell death specifically induced by H2O2, acting in very low concentrations (nanomolar range) and in very early stages of the neurotoxic intracellular process.(In Vivo):Pergolide (0.3 mg/kg; intraperitoneal injection; daily; 11 days) treatment reduces the number of working/reference memory errors a 6-OHDA-induced rat model of Parkinson's disease. Pergolide facilitates spatial memory and improves brain oxidative balance .

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 66104-23-2
• MW: 410.59
• Purity: >98% (HPLC)
• Formula: C₂₀H₃₀N₂O₃S₂
• SMILES: [H][C@@]1(N(CCC)C[C@H](CSC)C[C@@]12[H])CC3=CNC4=C3C2=CC=C4.CS(=O)(O)=O
• Target: 5-HT Receptor
• Solubility: DMSO 10 mg/mL;Water 82 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LY127809 | NSC 319773

Quick Database Links

Gene Symbol

5-HT Receptor