PF-00835231

SKU: orb1298084

Description

PF-00835231 is a potent and selective inhibitor of the SARS-CoV-2 3CL protease, demonstrating sub-nanomolar in vitro activity. As the active moiety of the first 3CLpro-targeting clinical candidate, it serves as a crucial research tool for studying coronavirus replication and for the development of antiviral therapeutics in both biochemical and cellular assays.

Research Area

Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 870153-29-0
• MW: 472.53
• Purity: 97.83% (May vary between batches)
• Formula: C₂₄H₃₂N₄O₆
• SMILES: COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)CO
• Target: SARS-CoV,HIV Protease,HCV Protease
• Solubility: DMSO:250 mg/mL (529.07 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (10.58 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SARS coronavirus, SARSCoV, SARS CoV-1, SARS CoV-1 3CLpro, SARS CoV-2, SARS-CoV, SARS-CoV-2, PF00835231, PF-00835231, PF 00835231, 3CLpro, COVID-19, Inhibitor, inhibit

Quick Database Links

Gene Symbol

SARS-CoV,HIV Protease,HCV Protease