PNU-159682

SKU: orb1307863

Description

PNU-159682 is a potent DNA topoisomerase II inhibitor derived from the anthracycline nemorubicin. This cytotoxic metabolite is utilized in cancer research to study its antitumor mechanisms in both in vitro and in vivo experimental models.

Research Area

Molecular Biology

Key Properties

• CAS Number: 202350-68-3
• MW: 641.62
• Purity: 98.24% (May vary between batches)
• Formula: C₃₂H₃₅NO₁₃
• SMILES: CO[C@H]1OCCN2[C@H]3C[C@H](O[C@H]4C[C@@](O)(Cc5c(O)c6C(=O)c7cccc(OC)c7C(=O)c6c(O)c45)C(=O)CO)O[C@@H](C)[C@H]3O[C@H]12
• Target: Topoisomerase,ADC Cytotoxin
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.14 mM);DMSO:96.7 mg/mL (150.71 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NMS249, NHL, non-Hodgkin's lymphoma, inhibit, Inhibitor, EDV nanocell, acute myeloid leukemia, ADC Payload, ADCs Toxin, ADCCytotoxin, ADC Cytotoxin, AML, Daunorubicins/Doxorubicins, Topoisomerase, topoisomerase I, PNU159682, PNU-159682, PNU 159682

Quick Database Links

Gene Symbol

Topoisomerase,ADC Cytotoxin