[Pyr1]-Apelin-13

SKU: orb1219858

Description

[Pyr1]-Apelin-13 is a potent and selective endogenous Apelin receptor (APJ) agonist.[Pyr1]-apelin-13 encapsulation in lipoPEG particles (lipoPEG-PA13) results in sustained and extended drug release under physiological conditions[1].[Pyr1]-apelin-13 nanocarriers in a mouse model of pressure-overload induced heart failure demonstrate a sustainable long-term effect of [Pyr1]-apelin-13 in preventing cardiac dysfunction. [Pyr1] apelin-13 (1, 5 μg) improves locomotor activity and reduces pain symptoms, cavity size and caspase-3 levels in rats. [Pyr1] apelin-13 (1, 5 μg) significantly increases thermal paw withdrawal latency. [Pyr1] apelin-13 in 5 μg dose also produces significant attenuation in paw withdrawal threshold compared to SCI animals from the second week post SCI.

Key Properties

• CAS Number: 217082-60-5
• MW: 1533.8
• Purity: >98% (HPLC)
• Formula: C₆₉H₁₀₈N₂₂O₁₆S
• SMILES: CSCCC(NC(=O)C1CCCN1C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC1=CNC=N1)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(N)=N)NC(=O)C1CCCN1C(=O)C(CCCNC(N)=N)NC(=O)C1CCC(=O)N1)C(=O)N1CCCC1C(=O)NC(CC1=CC=CC=C1)C(O)=O
• Target: endogenous apelin receptor
• Solubility: H2O:50 mg/mL (32.60 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

[pGlu1]-Apelin-13

Quick Database Links

Gene Symbol

endogenous apelin receptor