Radotinib

SKU: orb1305681

Description

Radotinib (IY-5511) is a small molecule Bcr-Abl tyrosine kinase inhibitor used in research for Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML), particularly in cases of resistance or intolerance to prior therapies. Its application extends to in vitro and in vivo studies investigating mechanisms of kinase inhibition and overcoming drug resistance in hematological malignancies.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 926037-48-1
• MW: 530.5
• Purity: 99.13% (May vary between batches)
• Formula: C₂₇H₂₁F₃N₈O
• SMILES: Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cnccn3)c2)cc(c1)C(F)(F)F
• Target: Apoptosis,STAT,Bcr-Abl,JAK
• Solubility: DMSO:5.31 mg/mL (10.01 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BcrAbl, Bcr-Abl1, IY 5511, IY5511, IY-5511, Supect, Radotinib

Quick Database Links

Gene Symbol

Apoptosis,STAT,Bcr-Abl,JAK