Rapamycin

SKU: orb1308282

Description

Rapamycin is a natural macrolide and potent mTOR inhibitor, demonstrating high specificity with an IC50 of 0.1 nM in HEK293 cells. This compound is widely used in research for its immunosuppressive properties and ability to induce autophagy, applicable in both in vitro mechanistic studies and in vivo models of aging and disease.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 53123-88-9
• MW: 914.2
• Purity: >98%
• Formula: C₅₁H₇₉NO₁₃
• SMILES: [H][C@@]12CC[C@@H](C)[C@@](O)(O1)C(=O)C(=O)N1CCCC[C@@]1([H])C(=O)O[C@@]([H])(CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C2)OC)[C@H](C)C[C@@H]1CC[C@@H](O)[C@@H](C1)OC
• Target: Kinase
• Solubility: Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 90 mg/ml).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Sirolimus; AY-22989; WY-090217; NSC-226080; Rapamune

Quick Database Links

Gene Symbol

Kinase