Resmetirom

SKU: orb1304018

Description

Resmetirom (MGL-3196) is an orally active, highly selective thyroid hormone receptor-beta (THR-β) agonist with an EC50 of 0.21 μM. It is a research compound used in studies of non-alcoholic steatohepatitis (NASH), with applications in both in vitro mechanistic studies and in vivo models of liver disease.

Research Area

Metabolism Research

Key Properties

• CAS Number: 920509-32-6
• MW: 435.22
• Purity: 99.05% (May vary between batches)
• Formula: C₁₇H₁₂Cl₂N₆O₄
• SMILES: CC(C)c1cc(Oc2c(Cl)cc(cc2Cl)-n2nc(C#N)c(=O)[nH]c2=O)n[nH]c1=O
• Target: Thyroid hormone receptor(THR)
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.58 mM);DMSO:101 mg/mL (232.07 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, MGL3196, MGL-3196, MGL 3196, inhibit, VIA 3196, VIA3196, VIA-3196, Resmetirom, THR-β, THR, Thyroidhormonereceptor, Thyroidhormonereceptor(THR), Thyroid hormone receptor(THR), Thyroid Hormone Receptor, Thyroid hormone receptor

Cas No. 920509-32-6

Quick Database Links

Gene Symbol

Thyroid hormone receptor(THR)