Rhynchophylline

SKU: orb1221800

Description

Rhynchophylline can protect against ischemic damage, probably via regulating the Akt/mTOR pathway. Rhynchophylline can protect against glutamate-induced neuronal death, can inhibit MA impairment in cultured neurons in vitro. Rhynchophylline and isorhynchophylline have a non-competitive antagonistic effect on the NMDA-type ionotropic glutamate receptors, suggest that these alkaloids exert their protective action against ischemia-induced neuronal damage by preventing NMDA, muscarinic M1, and 5-HT2 receptors-mediated neurotoxicity during ischemia.

Key Properties

• CAS Number: 76-66-4
• MW: 384.47
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₈N₂O₄
• SMILES: CCC1CN2CCC3(C2CC1C(=COC)C(=O)OC)C4=CC=CC=C4NC3=O
• Target: Others
• Solubility: DMSO : 33.33 mg/mL 86.69 mM; H2O : < 0.1 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Others