Rifabutin

SKU: orb1308428

Description

Rifabutin is a semisynthetic ansamycin antibiotic that potently inhibits bacterial DNA-dependent RNA polymerase, blocking transcription initiation. It is widely used in antimycobacterial research, including in vitro susceptibility assays and in vivo models for studying tuberculosis and MAC infections.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 72559-06-9
• MW: 847.00
• Purity: 98.87% (May vary between batches)
• Formula: C₄₆H₆₂N₄O₁₁
• SMILES: CO[C@H]1\C=C/O[C@@]2(C)Oc3c(C2=O)c2C4=NC5(CCN(CC(C)C)CC5)NC4=C(NC(=O)\C(C)=C/C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)C(=O)c2c(O)c3C
• Target: DNA/RNA Synthesis,HSP,Antibiotic,Antibacterial
• Solubility: DMSO:50 mg/mL (59.03 mM);Ethanol:38 mg/mL (44.86 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.36 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bacterial, Antibiotic, Ansamycin, DNA Synthesis, DNASynthesis, inhibit, LM 427, LM427, LM-427, HSP90, Inhibitor, Endoplasmin, Rifabutin, RNASynthesis, RNA polymerase, RNA Synthesis

Quick Database Links

Gene Symbol

DNA/RNA Synthesis,HSP,Antibiotic,Antibacterial