RK-33

SKU: orb1223437

Description

RK-33 is a potent and selective DDX3 inhibitor. RK-33 binds to DDX3 and abrogates its activity. Inhibition of DDX3 by RK-33 caused G1 cell cycle arrest, induced apoptosis, and promoted radiation sensitization in DDX3-overexpressing cells. Overall, inhibition of DDX3 by RK-33 promotes tumor regression, thus providing a compelling argument to develop DDX3 inhibitors for lung cancer therapy. RK-33 radiosensitizes prostate cancer cells by blocking the RNA helicase DDX3.

Key Properties

• CAS Number: 1070773-09-9
• MW: 428.44
• Purity: >98% (HPLC)
• Formula: C₂₃H₂₀N₆O₃
• SMILES: COC1=CC=C(C=C1)CN2C=NC3=C2N=CN=C4C3=NC(=O)N4CC5=CC=C(C=C5)OC
• Target: DDX3
• Solubility: In Vitro: DMSO : 50 mg/mL (116.70 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RK-33 | RK 33 | RK33.

Quick Database Links

Gene Symbol

DDX3