Ro 67-7476

SKU: orb1304163

Description

Ro 67-7476 is a potent and selective positive allosteric modulator of rat mGluR1a (EC50 = 60.1 nM), enhancing glutamate-induced calcium release. It also acts as a P-ERK1/2 agonist, independently stimulating ERK1/2 phosphorylation (EC50 = 163.3 nM). This compound is a valuable research tool for studying mGluR1 signaling in neurological disease models, both in vitro and in vivo.

Research Area

Neuroscience

Key Properties

• CAS Number: 298690-60-5
• MW: 319.39
• Purity: 99.48% (May vary between batches)
• Formula: C₁₇H₁₈FNO₂S
• SMILES: Cc1ccc(cc1)S(=O)(=O)N1CCC[C@H]1c1ccc(F)cc1
• Target: GluR
• Solubility: DMSO:50 mg/mL (156.55 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cAMP accumulation, Inhibitor, excitatory postsynaptic potentials, Metabotropic glutamate receptors, mGluR, mGluR1, neuronal culture, inhibit, traumatic injury, Ro 67 7476, Ro 677476, Ro 67-7476

Quick Database Links

Gene Symbol

GluR