RORγt inverse agonist 13

SKU: orb1297973

Description

Compound 3i is a potent and selective RORγt inverse agonist with an IC50 of 63.8 nM, demonstrating oral activity and favorable drug-like properties. It is a valuable research tool for investigating Th17 cell biology and autoimmune diseases in both cellular and animal models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2170477-75-3
• MW: 513.29
• Purity: 99.00% (May vary between batches)
• Formula: C₂₃H₁₇Cl₂F₃N₂O₄
• SMILES: OC(=O)Cc1ccc(CNC(=O)Nc2cc(Cl)c(c(Cl)c2)-c2ccccc2OC(F)(F)F)cc1
• Target: ROR
• Solubility: 10% DMSO+90% Corn Oil:1 mg/mL (1.95 mM);DMSO:10 mg/mL (19.48 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, ROR, RORγt inverse agonist13, RORγt inverse agonist-13, RORγt, RORγt inverse agonist 13, RORgammat inverse agonist 13, RORrt inverse agonist 13, RAR-related orphan receptor

Quick Database Links

Gene Symbol

ROR