Rucaparib monocamsylate

SKU: orb1307769

Description

Rucaparib camsylate is a potent PARP inhibitor with a Ki of 1.4 nM for PARP1 and affinity for eight other PARP family members. It is widely used in vitro and in vivo for cancer research, particularly in studies of BRCA-deficient tumors and synthetic lethality.

Research Area

Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1859053-21-6
• MW: 555.66
• Purity: 99.80% (May vary between batches)
• Formula: C₂₉H₃₄FN₃O₅S
• SMILES: [H][C@@]12CC[C@@](CS(O)(=O)=O)(C(=O)C1)C2(C)C.CNCc1ccc(cc1)-c1[nH]c2cc(F)cc3C(=O)NCCc1c23
• Target: PARP
• Solubility: DMSO:82.33 mg/mL (148.17 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (5.94 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BRCA2, Capan-1, BRCA1, AG14644, AG014699 monocamsylate, inhibit, MX-1, PARP, PARP1, PARP-1, NF-κB, poly ADP ribose polymerase, Inhibitor, H6PD, SSB, repair, Rucaparib Camsylate, Rucaparib monocamsylate, PF-01367338 monocamsylate

Quick Database Links

Gene Symbol

PARP