(S)-crizotinib

SKU: orb1300839

Description

(S)-Crizotinib (ent-crizotinib) is the (S)-enantiomer of crizotinib and acts as a potent MTH1 inhibitor with an IC50 of 72 nM. This small molecule is a valuable research tool for studying the role of MTH1 in DNA repair mechanisms, applicable in both in vitro and in vivo cancer research contexts.

Research Area

Cell Biology, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1374356-45-2
• MW: 450.34
• Purity: 98.52% (May vary between batches)
• Formula: C₂₁H₂₂Cl₂FN₅O
• SMILES: C[C@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
• Target: Apoptosis,MTH1,DNA/RNA Synthesis
• Solubility: 1eq. HCl:9 mg/mL (19.98 mM);DMSO:22.5 mg/mL (49.96 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.22 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNASynthesis, DNA/RNA Synthesis, DNA Synthesis, crizotinib, anticancer, Apoptosis, (S) crizotinib, (S)crizotinib, (S)-Crizotinib, activity, mutT, inhibit, MTH1, nucleotide, homologue, Inhibitor, ent-crizotinib, RNA Synthesis, RNASynthesis, pool

Quick Database Links

Gene Symbol

Apoptosis,MTH1,DNA/RNA Synthesis