S49076

SKU: orb1304357

Description

S49076 is a novel small molecule inhibitor targeting receptor tyrosine kinases MET, AXL/MER, and FGFR1/2/3. It effectively blocks their cellular phosphorylation and has demonstrated activity in preclinical in vitro and in vivo cancer models, supporting its use in oncology research.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1265965-22-7
• MW: 438.5
• Purity: 91.88% (May vary between batches)
• Formula: C₂₂H₂₂N₄O₄S
• SMILES: O=C1CSC(=O)N1Cc1ccc2NC(=O)\C(=C/c3cc(CN4CCOCC4)c[nH]3)c2c1
• Target: TAM Receptor,FGFR,c-Met/HGFR
• Solubility: DMSO:81 mg/mL (184.72 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.53 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Mer, Met, Fibroblast growth factor receptor, FGFR, FGFR3, FGFR2, Inhibitor, HGFR, c-Met/HGFR, c-Met, cMet/HGFR, cMet, AXL, S49076, S-49076, S 49076, TAMReceptor, TAM Receptor

Quick Database Links

Gene Symbol

TAM Receptor,FGFR,c-Met/HGFR