SAR-20347

SKU: orb1303059

Description

SAR-20347 is a potent small molecule inhibitor targeting the TYK2, JAK1, JAK2, and JAK3 kinases with respective IC50 values of 0.6, 23, 26, and 41 nM. This compound is a valuable research tool for investigating JAK/STAT signaling pathways in both cellular and animal models of autoimmune and inflammatory diseases.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1450881-55-6
• MW: 444.84
• Purity: 98.99% (May vary between batches)
• Formula: C₂₁H₁₈ClFN₄O₄
• SMILES: NC(=O)c1nc(oc1Nc1ccc(cc1)C(=O)N1CCOCC1)-c1c(F)cccc1Cl
• Target: Tyrosine Kinases,JAK
• Solubility: DMSO:55 mg/mL (123.64 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.5 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SAR20347, SAR-20347, SAR 20347, TyrosineKinases, Tyrosine Kinases, TYK2, JAK, JAK1, Janus kinase, inhibit, JAK2, JAK3, Inhibitor

Quick Database Links

Gene Symbol

Tyrosine Kinases,JAK