SB-649868

SKU: orb1301739

Description

SB-649868 (GSK649868) is a potent, selective, and orally bioavailable dual orexin receptor antagonist, exhibiting high affinity for both OX1 and OX2 receptors. It is a valuable research tool for investigating sleep-wake regulation, stress responses, and addiction pathways in both in vitro and in vivo models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 380899-24-1
• MW: 477.55
• Purity: 99.53% (May vary between batches)
• Formula: C₂₆H₂₄FN₃O₃S
• SMILES: Cc1nc(C(=O)N2CCCC[C@H]2CNC(=O)c2cccc3occc23)c(s1)-c1ccc(F)cc1
• Target: OX Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.38 mM);DMSO:100 mg/mL (209.4 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

OXReceptor, SB649868, SB-649868, SB 649868, inhibit, Inhibitor, OX Receptor, OX1, OX2, Orexin Receptor (OX Receptor), GSK 649868, GSK649868, GSK-649868, HCRT Receptor, Hypocretin Receptor

Quick Database Links

Gene Symbol

OX Receptor