SB225002

SKU: orb1306985

Description

SB225002 is a selective small molecule antagonist of the CXCR2 chemokine receptor, effectively blocking IL-8 binding. It is widely used in research to investigate CXCR2's role in neutrophil migration, inflammation, and cancer biology in both cellular and animal models.

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 182498-32-4
• MW: 352.14
• Purity: 96.86% (May vary between batches)
• Formula: C₁₃H₁₀BrN₃O₄
• SMILES: N(C(NC1=C(Br)C=CC=C1)=O)C2=C(O)C=C(N(=O)=O)C=C2
• Target: CXCR
• Solubility: DMSO:71.4 mg/mL (202.76 mM);Ethanol:3 mg/mL (8.52 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.68 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, CXCR2, CXCR, CXC chemokine receptors, SB 225002, SB225002, SB-225002

Quick Database Links

Gene Symbol

CXCR

Yan-Hua Zhao, Juan Chen, Tao Gong, Hai-Yan Ge, Min Li Icariin inhibits tumor-associated neutrophil recruitment via the CXCL8-CXCR2 axis and restrains pro-metastatic programs in colorectal cancer WJG, 32(11), 113325 (2026)

Applications

Cell Culture

Reactivity

Human