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SBI-0206965

SKU: orb1225827

Description

SBI-0206965 (SBI 0206965) is a potent and specific small molecule ULK1 kinase inhibitor with IC50 of 108 nM; displays 7-fold less potency for ULK2 (IC50=711 nM); inhibits Beclin1 Ser15 and Vps34 Ser249 phosphorylation to comparable extents in HEK-293T cells; suppresses autophagy induced by mTOR inhibition and prevents ULK1-dependent cell survival; greatly synergized with mTOR inhibitors to kill tumor cells.

Images & Validation

Key Properties

CAS Number1884220-36-3
MW489.3192
Purity>98% (HPLC)
FormulaC21H21BrN4O5
SMILESO=C(NC)C1=CC=CC=C1OC2=NC(NC3=CC(OC)=C(OC)C(OC)=C3)=NC=C2Br
TargetULK
Solubility10 mM in DMSO

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

SBI 0206965 | SBI0206965

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    1884220-36-3

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    C21H21BrN4O5

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SBI-0206965 (orb1225827)

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$ 80.00
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