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SC-43

SKU: orb1298899

Description

SC-43 is an orally bioavailable small molecule agonist of SHP-1 (PTPN6). Its mechanism involves inhibiting STAT3 phosphorylation, leading to pro-apoptotic effects demonstrated in vitro and in vivo. This activity underpins its research utility in oncology and fibrotic disease studies.

Research Area

Cell Biology, Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number1400989-25-4
MW431.8
Purity98.00% (May vary between batches)
FormulaC21H13ClF3N3O2
SMILESFC(F)(F)c1cc(NC(=O)Nc2cccc(Oc3ccc(cc3)C#N)c2)ccc1Cl
TargetSTAT,Phosphatase,Apoptosis
SolubilityDMSO:100 mg/mL (231.59 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (7.64 mM)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

anti-fibrotic, Apoptosis, apoptosis, anticancer, antiproliferative, caspase-3, PARP, orally, inhibit, Inhibitor, Phosphatase, SHP-1, p-STAT3, PTPN6, SC 43, SC43, SC-43, STAT, STAT3

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SC-43 (orb1298899)

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Available Sizes

Select a size below

1 mg
$ 140.00
5 mg
$ 230.00
1 ml x 10 mM (in DMSO)
$ 240.00
10 mg
$ 320.00
25 mg
$ 520.00
50 mg
$ 760.00
100 mg
$ 1,030.00
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