SCH900776 (S-isomer)

SKU: orb1303875

Description

SCH900776 S-isomer (MK-8776 S-isomer) is a potent, selective, and orally active Chk1 inhibitor with an IC50 of 3 nM, showing weaker activity against Chk2 and CDK2. It is widely used in cancer research to study DNA damage response and has demonstrated chemosensitizing effects in various preclinical in vitro and in vivo models.

Research Area

Cell Biology

Key Properties

• CAS Number: 891494-64-7
• MW: 376.25
• Purity: 98.69% (May vary between batches)
• Formula: C₁₅H₁₈BrN₇
• SMILES: Cn1cc(cn1)-c1cnn2c(N)c(Br)c(nc12)[C@H]1CCCNC1
• Target: Others,CDK,Chk
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.63 mM);DMSO:100 mg/mL (265.78 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CDK2, Chk1, Chk2, Inhibitor, MK-8776 S-isomer, inhibit, SCH900776, SCH-900776, SCH900776 (S isomer), SCH900776 (Sisomer), SCH-900776 (S-isomer), SCH900776 (S-isomer), SCH900776 S-isomer, SCH 900776, S-isomer

Quick Database Links

Gene Symbol

Others,CDK,Chk