Selinexor

SKU: orb1301068

Description

Selinexor (KPT-330) is an orally bioavailable, selective inhibitor of Exportin 1 (XPO1/CRM1). It induces cell cycle arrest and apoptosis, demonstrating antitumor activity in preclinical models of multiple myeloma, including both in vitro cell studies and in vivo xenograft experiments.

Research Area

Neuroscience

Key Properties

• CAS Number: 1393477-72-9
• MW: 443.3
• Purity: >98%
• Formula: C₁₇H₁₁F₆N₇O
• SMILES: FC(F)(F)c1cc(cc(c1)C(F)(F)F)-c1ncn(\C=C/C(=O)NNc2cnccn2)n1
• Target: CRM1
• Solubility: Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KPT-330

Quick Database Links

Gene Symbol

CRM1