Selitrectinib

SKU: orb1299822

Description

Selitrectinib (LOXO-195) is a highly potent and selective next-generation TRK inhibitor, targeting TrkA and TrkC with IC50 values of 0.6 and <2.5 nM, respectively. It is a valuable research tool for studying TRK-driven cancers, demonstrating activity in both cellular assays and in vivo models of acquired resistance to first-generation TRK inhibitors.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2097002-61-2
• MW: 380.42
• Purity: ≥95% (May vary between batches)
• Formula: C₂₀H₂₁FN₆O
• SMILES: [H][C@]12CCCN1c1ccn3ncc(C(=O)N[C@H](C)CCc4ncc(F)cc24)c3n1
• Target: Trk receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.26 mM);DMSO:65 mg/mL (170.86 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, LOXO195, LOXO-195, LOXO 195, Selitrectinib, Trk Receptor, Trkreceptor, Trk receptor, Trk, Tropomyosin related kinase receptor

Quick Database Links

Gene Symbol

Trk receptor