(+)-Shikonin

SKU: orb1309685

Description

(+)-Shikonin is a bioactive natural compound that acts as a TMEM16A chloride channel inhibitor and a selective PKM2 inhibitor. It has demonstrated antitumor and anti-inflammatory properties in research studies, supporting its investigation in cancer biology and inflammation models both in vitro and in vivo.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 517-89-5
• MW: 288.30
• Purity: 98.13% (May vary between batches)
• Formula: C₁₆H₁₆O₅
• SMILES: CC(C)=CC[C@@H](O)C1=CC(=O)c2c(O)ccc(O)c2C1=O
• Target: Chloride channel,TNF,HIV Protease,PKM,AIM2,NF-κB
• Solubility: Ethanol:13.00 mg/mL (45.09 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5.70 mg/mL (19.77 mM);DMSO:130.00 mg/mL (450.92 mM);H2O:Insoluble

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Chloride channel, Chloride Channel, Chloridechannel, Cl? Channels, Alkanna Red, (+)-Shikonin, (R)-(+)-Shikonin, C.I. 75535, Anchusa acid, NSC252844, NSC-252844, NSC 252844, Inhibitor, Isoarnebin 4, Isoarnebin4, Isoarnebin-4, inhibit, NF-kB, NFkB, Pyruvate Kinase, NF-κB, NFκB, Nuclear factor-kappaB, Nuclear factor-κB, Human immunodeficiency virus, HIV, HIV Protease, HIVProtease, Shikonin, TNF-α, TNFR, PKM2, TMEM16A chloride channel, TNF Receptor, Tumor Necrosis Factor Receptor

Quick Database Links

Gene Symbol

Chloride channel,TNF,HIV Protease,PKM,AIM2,NF-κB