Simeprevir

SKU: orb1302653

Description

Simeprevir (TMC435) is a small molecule NS3/4A protease inhibitor with potent anti-HCV activity, demonstrating an EC50 of 8 nM in replication assays. It has been widely used in both in vitro and in vivo research to study hepatitis C virus inhibition and combination antiviral therapies.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 923604-59-5
• MW: 749.94
• Purity: 99.45% (May vary between batches)
• Formula: C₃₈H₄₇N₅O₇S₂
• SMILES: COc1ccc2c(O[C@@H]3C[C@@H]4[C@@H](C3)C(=O)N(C)CCCC\C=C/[C@@H]3C[C@]3(NC4=O)C(=O)NS(=O)(=O)C3CC3)cc(nc2c1C)-c1nc(cs1)C(C)C
• Target: HCV Protease,DNA/RNA Synthesis,SARS-CoV
• Solubility: H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.33 mM);DMSO:55 mg/mL (73.34 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNA/RNA Synthesis, Huh7-Luc, Hepatitis C virus, HCV NS3/4A protease, HCV, HCVProtease, HCV Protease, Inhibitor, immune responses, inhibit, Olysio, Virus replication, RNA-dependent RNA polymerase, Remdesivir, SARSCoV, SARS-CoV, SARS coronavirus, Simeprevir, TMC 435, TMC 435350, TMC-435350, TMC435, TMC435350, TMC-435, RdRp

Quick Database Links

Gene Symbol

HCV Protease,DNA/RNA Synthesis,SARS-CoV