SN-38

SKU: orb1307686

Description

SN-38 (NK012) is the active metabolite of the Topoisomerase I inhibitor Irinotecan. It potently inhibits DNA/RNA synthesis and exhibits antitumor activity, including the induction of autophagy, making it a valuable tool for in vitro and in vivo cancer research.

Research Area

Cell Biology, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 86639-52-3
• MW: 392.41
• Purity: >98%
• Formula: C₂₂H₂₀N₂O₅
• SMILES: C(C)C1=C2C(C=3N(C2)C(=O)C4=C(C3)[C@](CC)(O)C(=O)OC4)=NC=5C1=CC(O)=CC5
• Target: Topoisomerase
• Solubility: Soluble in DMSO (up to 40 mg/ml).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ADC Payload, ADC Cytotoxin, ADCCytotoxin, Autophagy, DNA synthesis, DNA Synthesis, DNASynthesis, Inhibitor, inhibit, NK012, NK-012, NK 012, Topoisomerase, Topo I, RNA Synthesis, RNASynthesis, SN 38, SN38, SN-38

Quick Database Links

Gene Symbol

Topoisomerase