SNX2112

SKU: orb1300885

Description

SNX2112 (PF-04928473) is a potent, orally bioavailable small molecule inhibitor of Hsp90, exhibiting a dissociation constant (Kd) of 16 nM. It is utilized in cancer research to study oncogenic client protein degradation and has demonstrated antitumor activity in both cellular assays and animal xenograft models.

Research Area

Cell Biology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 908112-43-6
• MW: 464.48
• Purity: 98.75% (May vary between batches)
• Formula: C₂₃H₂₇F₃N₄O₃
• SMILES: CC1(C)Cc2c(c(nn2-c2ccc(C(N)=O)c(NC3CCC(O)CC3)c2)C(F)(F)F)C(=O)C1
• Target: HSP,Autophagy
• Solubility: Ethanol:1 mg/mL (2.15 mM);DMSO:86 mg/mL (185.15 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.1 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HSP90α, HSP90β, SNX 2112, SNX2112, SNX-2112, PF04928473, PF-04928473, PF 04928473

Quick Database Links

Gene Symbol

HSP,Autophagy