Sonidegib diphosphate

SKU: orb1308134

Description

Sonidegib diphosphate is a potent and selective Smoothened (Smo) antagonist, with IC50 values of 1.3 nM and 2.5 nM for murine and human targets, respectively. This tool compound is widely used in vitro and in vivo for researching Hedgehog pathway-driven cancers, such as basal cell carcinoma and medulloblastoma.

Research Area

Pharmacology & Drug Discovery, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1218778-77-8
• MW: 681.49
• Purity: 99.48% (May vary between batches)
• Formula: C₂₆H₃₂F₃N₃O₁₁P₂
• SMILES: OP(O)(O)=O.OP(O)(O)=O.C[C@H]1CN(C[C@@H](C)O1)c1ccc(NC(=O)c2cccc(-c3ccc(OC(F)(F)F)cc3)c2C)cn1
• Target: Smo
• Solubility: DMSO:99 mg/mL (145.27 mM);H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (4.84 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LDE 225, LDE 225 Diphosphate, LDE225, LDE-225, LDE225 diphosphate, LDE-225 Diphosphate, Erismodegib, Erismodegib diphosphate, hSmo, NVP-LDE 225, NVP-LDE 225 diphosphate, NVP-LDE225, NVP-LDE-225, NVP-LDE-225 Diphosphate, mSmo, Smo, Sonidegib

Quick Database Links

Gene Symbol

Smo