SP2509

SKU: orb1226307

Description

SP2509 is a potent, selective histone demethylase LSD1 (KDM1A) inhibitor with IC50 of 13 nM, shows no activity against MAOA, MAOB, LDH and glucose oxidase; inhibits the colony growth of OCI-AML3 significantly more than of the other AML cell-types, induces more apoptosis of AML cells expressing mutant NPM1 than mixed-lineage leukemia fusion oncoproteins; significantly improves the survival of immune-depleted mice model of AML, SP2509 is synergistically lethal against cultured and primary AML blasts combined with panobinostat.

Key Properties

• CAS Number: 1423715-09-6
• MW: 437.8972
• Purity: >98% (HPLC)
• Formula: C₁₉H₂₀ClN₃O₅S
• SMILES: O=C(N/N=C(C1=CC(Cl)=CC=C1O)\C)C2=CC=CC(S(=O)(N3CCOCC3)=O)=C2
• Target: Histone Demethylase
• Solubility: DMSO: ≥ 33 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SP-2509

Quick Database Links

Gene Symbol

Histone Demethylase