SR-717

SKU: orb1298740

Description

SR-717 is a non-nucleoside STING agonist analog of cGAMP that stabilizes the protein in a closed, active conformation. It has demonstrated antitumor efficacy in preclinical models by enhancing immune cell activation and antigen cross-presentation in both cellular and animal studies.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 2375421-09-1
• MW: 351.19
• Purity: 98.24% (May vary between batches)
• Formula: C₁₅H₈F₂LiN₅O₃
• SMILES: [Li+].[O-]C(=O)c1cc(F)c(F)cc1NC(=O)c1ccc(nn1)-n1ccnc1
• Target: STING
• Solubility: DMSO:20 mg/mL (56.95 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (7.12 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SR 717, SR717, SR-717, STING, Stimulator of Interferon Genes, TMEM173, THP1, inhibit, ISG-THP1, MPYS, PD-L1, MITA, mimetic, immunity, Inhibitor, ERIS, cGAMP, antitumor

Quick Database Links

Gene Symbol

STING