SR-1001

SKU: orb1302038

Description

SR 1001 is a potent inverse agonist targeting the nuclear receptors RORα and RORγ, with inhibitory constants (Kis) of 172 nM and 111 nM, respectively. It is a valuable chemical probe for studying Th17 cell biology, autoimmune mechanisms, and inflammatory diseases in both cellular and animal models.

Research Area

Cardiovascular Research, Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 1335106-03-0
• MW: 477.39
• Purity: >98%
• Formula: C₁₅H₁₃F₆N₆O₄S₂
• SMILES: CC(=O)Nc1nc(C)c(s1)S(=O)(=O)Nc1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F
• Target: Retinoid receptor and related
• Solubility: Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 40 mg/ml).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, RAR-related orphan receptor, ROR, RORα, RORγ, SR 1001, SR1001, SR-1001

Quick Database Links

Gene Symbol

Retinoid receptor and related