SRJ-23

SKU: orb1223816

Description

A novel semisynthetic derivative of andrographolide that directly target Ras to block the exchange of GDP for GTP and thus prevent Ras activation; significantly suppresses K-Ras GTP loading, whereas H-Ras and N-Ras GTP loading are much less sensitive; reduceds K-RasG12V GTP, phosphorylated ERK (ppERK) levels in K-RasG12V-transformed cells; induces G1 arrest and apoptosis in MCF-7 and HCT-116 cells, respectively.

Key Properties

• CAS Number: 865285-29-6
• MW: 317.704
• Purity: >98% (HPLC)
• Formula: C₁₅H₉ClFN₃O₂
• SMILES: O=C(NC1=NN=NN1CCC)C2=CC=CC(Cl)=C2
• Target: Ras
• Solubility: DMSO: Soluble （ < 1 mg/ml refers to the product slightly soluble or insoluble )

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SRJ23 | SRJ 23

Quick Database Links

Gene Symbol

Ras