(S,R,S)-AHPC-Me

SKU: orb1299538

Description

(S,R,S)-AHPC-Me is a potent VHL ligand derived from (S,R,S)-AHPC, designed for targeted protein degradation. It effectively degrades BET proteins with a DC50 below 1 nM in resistant prostate cancer cell models and serves as a key component in the synthesis of the PROTAC degrader ARV-771 for cancer research.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1948273-02-6
• MW: 444.59
• Purity: 99.86% (May vary between batches)
• Formula: C₂₃H₃₂N₄O₃S
• SMILES: C([C@H](C(C)(C)C)N)(=O)N1[C@H](C(N[C@@H](C)C2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1
• Target: Ligands for E3 Ligase,E3 Ligase Ligand-Linker Conjugates

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(S,R,S)AHPCMe, (S,R,S) AHPC Me, AHPC-Me, E3 ligase Ligand 1A, Ligands for E3 Ligase, Ligand for E3 Ligase, LigandforE3Ligase, inhibit, E3 ligase-recruiting Moiety, Inhibitor, VHL ligand 2, VHL ligand2, VHL ligand-2, VHL

Quick Database Links

Gene Symbol

Ligands for E3 Ligase,E3 Ligase Ligand-Linker Conjugates