Streptozocin (Streptozotocin)

SKU: orb1308404

Description

Streptozotocin is a GLUT2-transported antibiotic that selectively induces pancreatic β-cell apoptosis via DNA alkylation. It is extensively used to generate experimental models of diabetes in vivo and to study β-cell toxicity in vitro. Due to its instability, fresh preparation in solution is required.

Research Area

Cell Biology

Key Properties

• CAS Number: 18883-66-4
• MW: 265.2
• Purity: >97%
• Formula: C₈H₁₅N₃O₇
• SMILES: [C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)(NC(N(N=O)C)=O)C=O
• Target: DNA
• Solubility: Soluble in DMSO (up to 25 mg/ml) or in Water (up to 100 mg/ml)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Streptozotocin; U-9889

Quick Database Links

Gene Symbol

DNA

VI Sevastianov, AS Ponomareva, NV Baranova A Tissue-Engineered Construct Based on a Decellularized Scaffold and the Islets of Langerhans: A Streptozotocin-Induced Diabetic Model Life, (2024)

N. V. Baranova et al. Impact of pancreatic cell-engineered constructs on the islet apparatus in recipient rats with type I diabetes mellitus researchgate.net, (2025)