Suramin sodium salt

SKU: orb1226602

Description

Suramin sodium salt (BAY-205, NF-060) is an antitrypansomal drug that also possesses antitumor activity; inhibits CRL (Cullin-RING E3 ubiquitin ligases) activity by disrupting its ability to recruit Cdc34; induces accumulation of CRL substrates; also inhibits multiple viruses (ZIKVs, EV71).Parasite Infection Approved.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 129-46-4
• MW: 1429.171
• Purity: >98% (HPLC)
• Formula: C₅₁H₃₄N₆Na₆O₂₃S₆
• SMILES: O=C(C1=CC=C(C)C(NC(C2=CC(NC(NC3=CC(C(NC4=C(C)C=CC(C(NC5=C(C(S(=O)([O-])=O)=CC(S(=O)([O-])=O)=C6)C6=C(S(=O)([O-])=O)C=C5)=O)=C4)=O)=CC=C3)=O)=CC=C2)=O)=C1)NC7=CC=C(S(=O)([O-])=O)C8=C7C(S(=O)([O-])=O)=CC(S(=O)([O-])=O)=C8.[Na+].[Na+].[Na+].[Na+].[Na+].
• Target: E3 Ubiquitin Ligase
• Solubility: H2O: ≥ 200 mg/mL; DMSO: 5.6 mg/mL (Need warming)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Suramin hexasodium salt | BAY-205 | NF-060

Quick Database Links

Gene Symbol

E3 Ubiquitin Ligase