Suvorexant

SKU: orb146219

Description

Suvorexant (MK-4305) is a potent, selective, and orally bioavailable antagonist of OX1R and OX2R currently under clinical investigation as a novel therapy for insomnia.Suvorexant is an analytical reference standard categorized as a diazepane sedative.Formulations containing suvorexant show abuse potential similar to zolpidem in recreational polydrug users with a history of sedative and psychedelic drug use.2 Suvorexant is regulated as a Schedule IV compound in the United States. This product is intended for use in analytical forensic applications.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1030377-33-3
• MW: 450.9207
• Formula: C₂₃H₂₃CLN₆O₂
• SMILES: ClC1C([H])=C([H])C2=C(C=1[H])N=C(N1C([H])([H])C([H])([H])N(C(C3C([H])=C(C([H])([H])[H])C([H])=C([H])C=3N3N=C([H])C([H])=N3)=O)[C@]([H])(C([H])([H])[H])C([H])([H])C1([H])[H])O2

Storage & Handling

• Storage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(R)-(4-(5-Chlorobenzo[d]oxazol-2-yl)-7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone;Suvorexant MK4305;MK 4305;MK-4305;Suvorexant (MK-4305);[(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone;5-Chloro-2-[(5R)-5-methyl-4-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepan-1-yl]-1,3-benzoxazole;Suvorexant;[(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone;[(R)-4-(5-chlorobenzooxazol-2-yl)-7-methyl-[1,4]diazepan-1-yl](5-methy;5-chloro-2-{(5R)-5-methyl-4-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepan-1-yl}-1,3-benzoxazole;Belsomra?;DORA-analogue;EOS-61934;SUVOREXABT;MK-4305 (Suvorexant);Synonyms Suvorexant;Suvorexant (with 4 ints.);BELSOMRA;MK4305;081L192FO9;C23H23ClN6O2;((7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone;(R)-(4-(5-chlo

Chemical structure of Suvorexant (MK-4305).

Hiroki Endo et al. Dexamethasone induces sleep disruption in male mice and is associated with hyperactivation of orexin neurons Psychopharmacology (Berl) ., (2026)

PubMed: 41984203

Carlos Carrera-Cañas 1, Isabel de Andrés 1, Marta Callejo 1, Miguel Garzón 2 Hypocretin/orexin peptide release occurs mostly extrasynaptically, is self-controlled, and specifically enhanced in female rats Exp Neurol, (2025)

PubMed: 40846248

Gun Young Yoon et al. Disruption of the hypothalamic orexin system links SARS-CoV-2 infection to persistent cortical neuronal pathology bioRxiv, (2026)