TAK-243

SKU: orb1307707

Description

TAK-243 (MLN7243) is a potent and selective inhibitor of the ubiquitin-activating enzyme (UAE/UBA1) with an IC50 of 1 nM. It effectively blocks global protein ubiquitination, disrupting key cellular signaling pathways. This mechanism underlies its observed pro-apoptotic and antitumor effects in both in vitro and in vivo cancer research models.

Research Area

Cell Biology, Epigenetics & Chromatin, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 1450833-55-2
• MW: 519.52
• Purity: 98.09% (May vary between batches)
• Formula: C₁₉H₂₀F₃N₅O₅S₂
• SMILES: NS(=O)(=O)OC[C@H]1C[C@@H](Nc2ccnc3cc(nn23)-c2cccc(SC(F)(F)F)c2)[C@H](O)[C@@H]1O
• Target: Apoptosis,E1/E2/E3 Enzyme,NF-κB
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (9.62 mM);DMSO:237.5 mg/mL (457.15 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, E3Enzyme, E2 conjugating enzyme, E2 Enzyme, E2Enzyme, E3 Enzyme, E3 ligating enzyme, E1 activating enzyme, E1 Enzyme, E1/E2/E3 Enzyme, E1Enzyme, Inhibitor, inhibit, NF-κB, NFκB, NF-kB, NFkB, MLN 7243, MLN7243, MLN-7243, Nuclear factor-kappaB, Nuclear factor-κB, UBA1, Ubiquitin activating enzyme, Ubiquitin conjugating enzyme, Ubiquitin ligase, TAK 243, TAK243, TAK-243

Quick Database Links

Gene Symbol

Apoptosis,E1/E2/E3 Enzyme,NF-κB