TAME hydrochloride

SKU: orb1225913

Description

TAME is a small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor that binds to the APC preferentially suppresses APC/C(Cdc20) rather than APC/C(Cdh1); inhibits cyclin proteolysis in mitotic Xenopus egg extract with IC50 of 12 uM; promotes Cdc20 autoubiquitination, blocks cyclin degradation in interphase extract.

Key Properties

• CAS Number: 1784-03-8
• MW: 378.87
• Purity: >98% (HPLC)
• Formula: C₁₄H₂₂N₄O₄S.HCl
• SMILES: N=C(N)NCCC[C@@H](C(OC)=O)NS(=O)(C1=CC=C(C)C=C1)=O.[H]Cl
• Target: E3 Ubiquitin Ligase
• Solubility: DMSO: 37.9 mg/mL (100 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tosyl-L-arginine methyl ester hydrochloride

Quick Database Links

Gene Symbol

E3 Ubiquitin Ligase