Temuterkib

SKU: orb1303171

Description

Temuterkib (LY3214996) is an oral, potent, and selective ERK1/2 inhibitor with antineoplastic potential. It is used in cancer research, particularly for studying MAPK pathway-driven tumors, and has demonstrated activity in both in vitro cellular assays and in vivo xenograft models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1951483-29-6
• MW: 453.56
• Purity: 99.37% (May vary between batches)
• Formula: C₂₂H₂₇N₇O₂S
• SMILES: Cn1nccc1Nc1nccc(n1)-c1cc2C(=O)N(CCN3CCOCC3)C(C)(C)c2s1
• Target: ERK
• Solubility: DMSO:7.36 mg/mL (16.23 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.2 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, LY3214996, LY-3214996, LY 3214996, Inhibitor, ERK1, ERK2, ERK, Extracellular signal regulated kinases, Temuterkib

Quick Database Links

Gene Symbol

ERK