Thailanstatin A

SKU: orb1303603

Description

Thailanstatin A is an ultra-potent eukaryotic RNA splicing inhibitor that non-covalently targets the SF3b subunit, exhibiting low-nanomolar cytotoxicity against various cancer cell lines. It serves as a potent payload for antibody-drug conjugates (ADCs), such as when conjugated to trastuzumab, and is used in cancer research for both in vitro and in vivo studies of spliceosome inhibition.

Key Properties

• CAS Number: 1426953-21-0
• MW: 535.63
• Purity: 93.69% (May vary between batches)
• Formula: C₂₈H₄₁NO₉
• SMILES: C[C@H](OC(C)=O)\C=C/C(=O)N[C@@H]1C[C@H](C)[C@H](C\C=C(/C)\C=C\[C@H]2O[C@H](CC(O)=O)C[C@@]3(CO3)[C@@H]2O)O[C@@H]1C
• Target: ADC Cytotoxin
• Solubility: DMSO:245 mg/mL (457.41 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

antiproliferative, ADC, ADCCytotoxin, ADC Cytotoxin, ADC Payload, inhibit, Inhibitor, linker, natural, RNA, spliceosome, subunit, SF3b, Thailanstatin A

Quick Database Links

Gene Symbol

ADC Cytotoxin