THIQ

SKU: orb1298894

Description

THIQ is a potent and selective agonist of the melanocortin-4 receptor (MC4R), demonstrating high affinity with IC50 values of 1.2 nM for human and 0.6 nM for rat receptors. This small molecule is a valuable research tool for studying energy homeostasis and obesity in both in vitro binding assays and in vivo metabolic studies.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 312637-48-2
• MW: 589.17
• Purity: 95.28% (May vary between batches)
• Formula: C₃₃H₄₁ClN₆O₂
• SMILES: ClC1=CC=C(C[C@@H](NC(=O)[C@H]2CC3=CC=CC=C3CN2)C(=O)N2CCC(CN3C=NC=N3)(CC2)C2CCCCC2)C=C1
• Target: Melanocortin Receptor
• Solubility: DMSO:245 mg/mL (415.84 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (8.49 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

affinity, activity, Inhibitor, MC Receptor, melanocortin, Melanocortin Receptor, melanocortin-4 receptor (MC4R), MelanocortinReceptor, erectile, eliciting, mutant, inhibit, selective, THIQ

Quick Database Links

Gene Symbol

Melanocortin Receptor