Thrombin Receptor Agonist peptide

SKU: orb216831

Description

Thrombin Receptor Agonist peptide

Research Area

Pharmacology & Drug Discovery

Images & Validation

• Application Notes:
  Cloning and expression of a functional human thrombin receptor have revealed a protein with seven transmembrane domains and a large extracellular amino-terminal extension. Thrombin cleaves within this extension, thereby creating a new receptor amino-terminus that functions as a tethered ligand and activates the receptor. A 14-amino acid peptide mimicking this new amino-terminus has been found to be a potent thrombin receptor activator as well as an effective agonist for platelet activation.

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Key Properties

• Source: Synthetic
• CAS Number: 137339-65-2
• MW: 1739.96
• Purity: > 95%
• Formula: C₈₁H₁₁₈N₂₀O₂₃
• Protein Sequence: H-Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe-OH

Storage & Handling

• Storage: Shipped at 4°C. Store at -20°C for one year.
• Form/Appearance: Lyophilized powder
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Thrombin Receptor Activator Peptide 14, PAR-1 (1-14) (human), Proteinase Activated Receptor 1 (1-14) (human), Thrombin Receptor (1-14) (human), Coagulation Factor II Receptor (1-14) (human)

Chemical structure of orb216831.