Tirofiban

SKU: orb1301003

Description

Tirofiban (L700462, MK-383) is a potent and selective antagonist of the platelet GPIIb/IIIa receptor, inhibiting aggregation with an IC50 of 9 nM. It is widely used in cardiovascular research to study thrombosis and has been applied in both in vitro platelet function assays and in vivo models of arterial injury.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 144494-65-5
• MW: 440.6
• Purity: 99.83% (May vary between batches)
• Formula: C₂₂H₃₆N₂O₅S
• SMILES: CCCCS(=O)(=O)N[C@@H](Cc1ccc(OCCCCC2CCNCC2)cc1)C(O)=O
• Target: Integrin
• Solubility: 1M HCL:54 mg/mL (122.56 mM);DMSO:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

antithrombotic, AMI, Aggrastat, ACSs, Integrin, Inhibitor, HUVEC, L700462, L-700462, GPIIb/IIIa, HAEC, inhibit, L 700462, MK 383, MK383, MK-383, Tirofiban, VEGF

Quick Database Links

Gene Symbol

Integrin