Trametinib (DMSO solvate)

SKU: orb1301426

Description

Trametinib (DMSO solvate), also known as GSK1120212, is a highly potent and selective allosteric inhibitor of MEK1 and MEK2 kinases with an IC50 of 2 nM. It is widely used in both in vitro and in vivo cancer research, particularly for studying the MAPK/ERK pathway in melanoma, NSCLC, and other malignancies.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 1187431-43-1
• MW: 693.53
• Purity: 98.82% (May vary between batches)
• Formula: C₂₈H₂₉FIN₅O₅S
• SMILES: CS(C)=O.CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O
• Target: Apoptosis,MEK
• Solubility: DMSO:1.3 mg/mL (1.87 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.44 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

type, Trametinib, Trametinib (DMSO solvate), Trametinib dimethyl sulfoxide, Trametinib DMSO solvate, JTP74057, JTP-74057, JTP-74057 (DMSO solvate), JTP 74057, inhibit, Mitogen-activated protein kinase kinase, orally, Inhibitor, MEK1/2, MEK, MAPKK, MAP2K, GSK 1120212, GSK1120212, GSK-1120212, GSK-1120212 (DMSO solvate), AIA, Adjuvant-induced, arthritis, Apoptosis, CIA, collageninduced, DMSO solvate

Chemical structure of Trametinib (DMSO solvate)

Quick Database Links

Gene Symbol

Apoptosis,MEK