Tropisetron

SKU: orb1305915

Description

Tropisetron (ICS 205-930) is a dual-acting small molecule, functioning as a potent α7-nicotinic acetylcholine receptor agonist and a 5-HT3 receptor antagonist with respective Ki values of 6.9 nM and 5.3 nM. It is widely used in neuroscience research to investigate cholinergic and serotonergic systems in models of cognition, inflammation, and nausea, both in vitro and in vivo.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Molecular Biology, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 89565-68-4
• MW: 284.35
• Purity: 99.68% (May vary between batches)
• Formula: C₁₇H₂₀N₂O₂
• SMILES: CN1[C@H]2CC[C@H]1CC(C2)OC(=O)c1c[nH]c2ccccc12
• Target: AChR,5-HT Receptor,JAK,p38 MAPK,DNA/RNA Synthesis,NF-κB
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.03 mM);DMSO:65 mg/mL (228.59 mM);H2O:50 mg/mL (175.84 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Serotonin Receptor, α7 nAChR, Tropisetronum, Tropisteron, Tropisetron, Inhibitor, ICS 205-930, inhibit, nAChR, Nicotinic acetylcholine receptors, 5HTReceptor, 5-hydroxytryptamine Receptor, 5HT Receptor, 5-HT Receptor, 5-HT3

Quick Database Links

Gene Symbol

AChR,5-HT Receptor,JAK,p38 MAPK,DNA/RNA Synthesis,NF-κB