Turofexorate Isopropyl

SKU: orb1301116

Description

Turofexorate Isopropyl (XL335) is a potent, selective, and orally active FXR agonist exhibiting an EC50 of 4 nM. It is a valuable research tool for investigating FXR's role in metabolic diseases, including non-alcoholic steatohepatitis (NASH), and has demonstrated efficacy in both in vitro assays and in vivo preclinical models.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 629664-81-9
• MW: 438.47
• Purity: 98.55% (May vary between batches)
• Formula: C₂₅H₂₄F₂N₂O₃
• SMILES: CC(C)OC(=O)C1=CN(CC(C)(C)c2c1[nH]c1ccccc21)C(=O)c1ccc(F)c(F)c1
• Target: FXR,Autophagy
• Solubility: DMSO:31 mg/mL (70.7 mM);Ethanol:2 mg/mL (4.56 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.56 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, NR1H4, Inhibitor, FXR, FXR 450, FXR450, FXR-450, Autophagy, XL 335, XL335, XL-335, WAY 362450, WAY362450, WAY-362450, Turofexorate Isopropyl

Quick Database Links

Gene Symbol

FXR,Autophagy